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Rich Experience in Safe Fluorination Technologies and HF Handling
NFIL has more than four decades of experience in designing and implementing innovative and cost effective fluorination processes. Our fluorination capabilities include catalytic, non-catalytic, gas phase and liquid phase fluorinations and other specialised fluorination reactions like Balz-Schiemann, Schiemann and Swartz using AHF and Halex using alkali metal fluorides
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Our Technological Expertise spans:
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- Fluorinations – with metal fluorides (Halex), anhydrous HF, HF amine complexes, SF4 ( under high pressure) and F2 gas
- High pressure synthesis – using catalytic hydrogenation and hydro-dechlorinations, ammonolysis, hydroxylation, halogen exchange using HF, Kolbe reaction
- Vapour phase synthesis – using alkylation, fluorination, ammoxidation, chlorination, hydrolysis, oxidation.
- Diazotizations – fluorination (Schiemann reaction and Balz-Schiemann reaction), bromination and chlorinations (Sandmeyer Reactions), hydrolysis to phenols, deamination and Meerwein arylation
- Other capabilities - nitration, bromination, chlorination, acylation, chlorosulfonation, condensation, methoxylation, organometallic chemistry, Grignard reaction and n-BuLi applications. Reductive deamination with sodium borohydride, hydrogen peroxide oxidation, Friedel – Crafts acylation, Fries Rearrangement, Kolbe’s synthesis and hydrolysis.
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Process scale up and technology transfer
We are one of the few companies in fluorination chemistry with the experience, capability and expertise in scale up from research
to pilot and manufacturing.
Our dedicated teams manage projects from development trials to final delivery of the desired compound.
The pilot facility at our Surat can simulate full scale production conditions and provide seamless transition from laboratory
to production plants.
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